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Saturday, October 10, 2020 | History

2 edition of Studies on desensitization in delayed hypersensitivity. found in the catalog.

Studies on desensitization in delayed hypersensitivity.

Liisa Jokipii

Studies on desensitization in delayed hypersensitivity.

by Liisa Jokipii

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  • 35 Currently reading

Published by University of Helsinki, Department of Serology and Bacteriology in Helsinki .
Written in English


Edition Notes

Academic dissertation to be publicly discussed, by permission of the Medical Faculty in the University of Helsinki, in Auditorium X11 on June 30, 1972, at 12 o"clock noon.

ID Numbers
Open LibraryOL21259518M
ISBN 109519900284

  In tuberculosis treatment, regimens containing second-line medications are known to be more toxic and less effective than those with first-line agents. Therefore, desensitization for delayed drug hypersensitivity to anti-tuberculosis medications may be a more effective treatment option than changing the regimen to a second-line one.   Only in 1 of the 10 desensitizations did the procedure last longer (35 days) than desired (16 days); however, this was still shorter than the previously published data of 6 weeks. 13 Both ENDA and the EAACI Interest Group on Drug Hypersensitivity advised that desensitization protocols should be performed in large samples of at least 10 patients.

Two delayed hypersensitivity Systems were used, i.e. tuberculin hypersensitivity evoked by BCG infection and hypersensitivity to diphtheria toxoid produced by immunization with specific precipitate in adjuvants. The ability of lymph node cells and spleen cells of hypersensitive guinea pigs to transfer skin and systemic hypergensitivity afterin vitro incubation with specific and nonspecific. Pharmacologic desensitization Hypersensitivity Type II -Known as tissue-specific, cytotoxic or cytolytic hypersensitivity -Often immediate reaction, but some occur over time -Antibodies attack antigens on surface of specific cells or tissues causing lysis Transfusion Reaction Individual receives blood from someone with a different blood group type Recipient antibodies attach to the donor’s.

This issue of Immunology and Allergy Clinics, guest edited by Mariana Castells, is devoted to Drug Hypersensitivity and Desensitizations. Articles in this issue include: Principles and Practice of Drug Desensitization; Incidence and Prevalence of Drug Hyp. Most studies published to date deal mainly with reactions to the beta-lactam group, and information on hypersensitivity to each of the other antimicrobial agents is scarce.


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Studies on desensitization in delayed hypersensitivity by Liisa Jokipii Download PDF EPUB FB2

Arthus reactions also manifest carrier specificity, although to a smaller extent than do delayed hypersensitivity reactions. Desensitization by injection of minute doses of antigen results in moderate specific desensitization of delayed hypersensitivity without desensitization of Arthus reactivity to the same antigenic determinant.

by: Desensitization in delayed‐type drug hypersensitivity may be possible and may enable to continue an effective and safe treatment. However, there have been no controlled clinical trials, very few well‐documented cases and the underlying pathophysiology is largely unknown In addition, published desensitization success rates are questionable, because in many patient series, the diagnosis of drug hypersensitivity has not been confirmed by prior allergological testing Cited by: Background: Delayed drug hypersensitivity to first-line anti-tuberculosis medication is a major challenge in tuberculosis treatment.

Objective: This study was performed to investigate the efficacy/tolerability of desensitization therapy in treatment of first-line anti-tuberculosis medication hypersensitivity and the usefulness of immunologic evaluation by: 4.

Arthus reactions also manifest carrier specificity, although to a smaller extent than do delayed hypersensitivity reactions. Desensitization by injection of minute doses of antigen results in moderate specific desensitization of delayed hypersensitivity without desensitization of Arthus reactivity to the same antigenic determinant.

by: Objective: To evaluate the outcomes of anti-tuberculosis drug desensitization. Methods: This was a retrospective study. Inclusion criteria were as follows: age >18years, documented tuberculosis infection, a previous cutaneous allergic reaction to anti-tuberculosis drugs, and having undergone drug desensitization between January and March Cited by: Objective: Administration of paclitaxel is associated with hypersensitivity reactions (HSRs) in up to 9% of patients despite premedication.

The purpose of this study was to evaluate the effectiveness of a standardized desensitization protocol in patients with HSRs to taxanes, based Studies on desensitization in delayed hypersensitivity.

book our experience with carboplatin desensitization. Abstract. A preliminary experiment showed that the injection of bovine γ-globulin into guinea-pigs with delayed hypersensitivity to bovine γ-globulin reduced the hour skin reactions to bovine γ-globulin and (to a lesser extent) PPD.

The peritoneal exudate cells from the desensitized donors had a reduced ability to transfer delayed hypersensitivity to bovine γ-globulin but a normal ability to transfer delayed. Title:A Novel Desensitization Protocol for Infliximab Hypersensitivity in a Year Old Patient with Pustular Psoriasis VOLUME: 14 ISSUE: 2 Author(s):Sapan Kumar Behera, Sandhiya Selvarajan*, Jerene Mathews, Chandana Shajil, Saibal Das, Malathi Munisamy and Alphienes Stanley Xavier Affiliation:Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical.

Anne Y. Liu MD, in Drug Allergy Testing, Desensitization. Rapid desensitization can be considered for anaphylaxis-type HSRs (immediate or delayed) and severe TIRs. Many desensitization protocols have been published, some of which are listed in Table ; the largest report of mAb desensitizations employed a three-bag, step protocol that started the infusion at 1/ of the final.

Type IV hypersensitivity is involved in the pathogenesis of many autoimmune and infectious diseases (tuberculosis, leprosy, blastomycosis, histoplasmosis, toxoplasmosis, leishmaniasis, etc.) and granulomas due to infections and foreign antigens. Another form of delayed hypersensitivity is contact dermatitis (poison ivy (figure 6), chemicals, heavy metals, etc.) in which the lesions are more.

INTRODUCTION. Desensitization is a procedure that alters the immune response to the drug and results in temporary tolerance, allowing the patient with a drug hypersensitivity reaction to receive an uninterrupted course of the medication safely. Once the medication is discontinued or if treatment is interrupted for a sufficient period of time, the patient's hypersensitivity to the medication.

the expert panel concerning desensitization in delayed drug hypersensitivity as a consensus statement. Definitions In the context of diagnostic and therapeutic procedures in hypersensitivity reactions to drugs, many different terms and definitions have been used in the literature, which are some-times overlapping.

Background: Chemotherapy is one of the main treatments for lung cancer, and in these patients, discontinuation of treatment due to uncontrollable hypersensitivity reactions (HSRs) is an important problem. Aim: To determine the frequency of HSRs during chemotherapy and to review current approaches.

Methods: We did a cross sectional study in patients undergoing chemotherapy for lung. This issue of Immunology and Allergy Clinics guest edited by Mariana Castells is devoted to Drug Hypersensitivity and Desensitizations.

Articles in this issue include: Principles and Practice of Drug Desensitization; Incidence and Prevalence of Drug Hyp. Clinicians must additionally be aware of the possibility of delayed hypersensitivity reactions. Hospital Clinic Barcelona) for the performance of the allergy studies and the design of desensitization protocol for case 1.

This is an analysis of patient cases that were enrolled in studies sponsored by Alexion Pharmaceuticals, Inc. Although. There are early studies using oral therapy for desensitization of food allergies that are promising. 11 12 These studies involve feeding children who have allergies tiny amounts of the allergen (e.g., peanut flour) or related proteins over time.

Many of the subjects show reduced severity of reaction to the food allergen after the therapy. Drug allergy encompasses a spectrum of immunologically-mediated hypersensitivity reactions with varying mechanisms and clinical presentations.

This type of adverse drug reaction not only affects patient quality of life, but may also lead to delayed treatment, unnecessary investigations, and even mortality. Given the myriad of symptoms associated with the condition, diagnosis is often.

The aim of this study was to evaluate the effects of drug desensitization on some cytokine levels in patients desensitized for drug hypersensitivity reactions. Methods Patients with a hypersensitivity reaction to any drug for whom desensitization was planned with the culprit drug, patients who could tolerate the same drugs and healthy subjects.

Delayed drug hypersensitivity to first-line anti-tuberculosis medication is a major challenge in tuberculosis treatment. Objective This study was performed to investigate the efficacy/tolerability of desensitization therapy in treatment of first-line anti-tuberculosis medication hypersensitivity and the usefulness of immunologic evaluation therein.

Delayed reactions: Clinical studies revealed cross-reactivity between (amino-)penicillins and aminocephalosporins in fewer than 40% of subjects. Thus, of the subjects who had experienced a delayed reaction to penicillins (primarily aminopenicillins) in the past, % tested positive in skin testing with aminopenicillins [ 25 ].

Taxanes (a class of chemotherapeutic agents) are an important cause of hypersensitivity reactions (HSRs) in cancer patients. During the last decade, the development of rapid drug desensitization has been key to allow patients with HSRs to taxanes to be safely re-treated although the mechanisms of these HSRs are not fully understood.

Hypersensitivity reactions to commonly used chemotherapeutic agents range from mild cutaneous eruptions to fatal anaphylaxis.

These are mostly immediate reactions 1 that may be amenable to desensitization procedures. 2 Nonimmediate reactions are less frequently reported and are challenging to manage. 1. Trastuzumab (Herceptin; F. Hoffmann-La Roche/Genentech, Nutley, NJ) is .usage vs desensitization.

Desensitization is becoming more commonly used in the current era of increasing antibiotic resistance and limited antimicrobial drug development [4]. This review focuses on the pathogene-sis, clinical manifestations, diagnosis, and treatment of immediate and delayed-type hypersensitivity reactions.